An unusual presentation of Krukenberg tumor in a young female patient: A case report

Laishram Purnima Devi, Manika Aggarwal, Jaya Mishra, Baphiralyne Wankhar, Mostafa Muhammad Ali Aman

Abstract


Krukenberg tumor is an uncommon metastatic tumor of the ovary. It usually presents in female with an average age of 45 years and constitutes 1-2% of all ovarian neoplasms. 30% of all ovarian neoplasms occurring during childhood and adolescence are malignant. A 22-year-old unmarried lady presented with painless abdominal distension with amenorrhea. On examination, 18-week lump was palpable. This lump was firm to hard in consistency, non-tender, and mobile. On ultrasonography, bilateral ovarian tumors were reported, with peritoneal free fluid. Laparotomy with right salpingo-oophorectomy and enucleation of left ovarian mass was performed. Microscopic examination revealed bilateral signet ring cells carcinoma of the ovaries probably metastatic origin with intact capsule. Tumor cells exhibited strong, diffuse immunopositivity for cytokeratin (CK) 7 and CK 20. Diagnosis of Krukenberg tumor was made. Repeated endoscopic biopsy confirmed the diagnosis of signet ring cell carcinoma stomach. This case is reported because of its rarity in younger age group, diagnostic dilemma, and poor prognosis.

Keywords


Cytokeratin 7, Cytokeratin 20, Immunohistochemistry, Krukenberg, Signet ring cell carcinoma

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