Skin mediated human papillomavirus infection in breast: A report of four cases

  • Saimul Islam
  • Hemantika Dasgupta
  • Mukta Basu
  • Anup Roy
  • Neyaz Alam
  • Gautam Kumar Mandal
  • Susanta Roychoudhury
  • Chinmay Kumar Panda

Abstract

To address the ambiguity of different modes of human papillomavirus (HPV) transmission in breast, the immunohistochemical expression of two oncoproteins E6/E7 of HPV16 was analyzed in primary breast cancer (BC) and adjacent normal skin of 4 samples. The patients were of 35–55 years old having no previous history of cancer. The E6/E7 expressions were evident in both skin and BC. In skin, high/moderate cytoplasmic expressions of E6/E7 proteins were seen in all samples, whereas in BC, high/moderate cytoplasmic expressions of the proteins were observed in 2–3 samples. Thus, it seems that HPV infection in the breast may occur through the skin.

Keywords: Breast cancer, breast skin, E6/E7 oncoproteins, human papillomavirus, human papillomavirus transmission
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How to Cite
Islam, S., Dasgupta, H., Basu, M., Roy, A., Alam, N., Mandal, G., Roychoudhury, S., & Panda, C. (2018). Skin mediated human papillomavirus infection in breast: A report of four cases. Indian Journal of Case Reports, 4(2), 98-102. Retrieved from https://atharvapub.net/IJCR/article/view/792
Section
Case Report