Epidemiology and seropositivity of dengue fever cases in a tertiary care hospital of NCR in 2013

Shilpi Gupta, Sachin Bansal


Background: Dengue has been known to be endemic in India for over two centuries. Dengue fever is more commonly seen in adults and older children. Clinical presentation varies from mild to severe fatal forms; therefore, laboratory diagnosis is very essential. Objective: The surveillance study was conducted to analyze dengue seropositivity and epidemiological profile among patients with dengue fever like illness who presented to the outpatient department or was admitted to a tertiary care private hospital in Ghaziabad,
Uttar Pradesh from January 2013 to December 2013. Materials and Methods: Serum samples from 1186 clinically suspected dengue fever cases (671 males and 515 females) were received in serology laboratory over the period of 1 year. The samples were screened for non-structural protein 1 (NS1) antigen and IgM and IgG dengue specific antibodies by rapid immunochromatographic
test. Results: Out of total 1186 blood samples tested, 574 were found to be positive for dengue infection. Of 574 blood samples, NS1 Ag was positive in 498 (86.7%) cases while IgM with or without NS1 Ag was positive in 15 (2.6%) cases. Conclusion: A detailed and continuous epidemiological surveillance is required for monitoring the incursions and spread of dengue viruses. This will help in undertaking and implementing effective control and management strategies.


Dengue specific IgG, Dengue specific IgM, Dengue, Epidemiology, Immunochromatographic test, Non-structural protein 1 Ag

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